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September 13, 2005Journal of Internal MedicineOpen Access

Abnormal angiopoietins 1&2, angiopoietin receptor Tie‐2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage a sub‐study of the Anglo‐Scandinavian Cardiac Outcomes Trial (ASCOT)

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Why the study?

Are plasma and platelet levels of angiogenic growth factors (VEGF, Ang-1, Ang-2, Tie-2) elevated in patients with hypertension and target organ damage compared to normotensive controls?

Population

273 adults, comprising 199 patients with hypertension and 74 healthy normotensive controls.

Design

Cross-sectional

Authors

SNSunil NadarRussells Hall HospitalABAndrew D. BlannVascular MedicineDBD G BeeversUniversity of Salford

Discussion

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Overview

These elevations should not alter hypertension management; hypothesis-generating for angiogenesis in target organ damage.

Structured PICO

Are plasma and platelet levels of angiogenic growth factors (VEGF, Ang-1, Ang-2, Tie-2) elevated in patients with hypertension and target organ damage compared to normotensive controls?

P
Population
273 adults, comprising 199 patients with hypertension (mean age 68 years, 75% men; 125 with evidence of target organ damage including stroke, previous MI, angina, LVH, and mild renal failure) and 74 healthy normotensive controls (mean age 68 years, 69% men).
C
Comparator
Healthy normotensive controls
O
Outcome
Plasma levels of VEGF, Ang-1, Ang-2, Tie-2, and total platelet levels of VEGF and Ang-1surrogate

Hypertensive patients, particularly those with target organ damage, exhibit elevated plasma and platelet levels of angiogenic growth factors, suggesting a role for abnormal angiogenesis and platelet activation in hypertensive target organ damage.

Cite This Study

Nadar et al. (2005) studied this question.

synapsesocial.com/papers/6a70812c35aa2c282ce1d3cfhttps://doi.org/10.1111/j.1365-2796.2005.01550.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypertension and Angiogenesis2003 · 73 citations
  2. 2The Prothrombotic State in Hypertension and the Effects of Antihypertensive Treatment2003 · 80 citations
  3. 3Platelet P-Selectin Levels in Relation to Plasma Soluble P-Selectin and β-Thromboglobulin Levels in Atrial Fibrillation2002 · 74 citations
  4. 4Plasma Angiopoietin-1, Angiopoietin-2, Angiopoietin Receptor Tie-2, and Vascular Endothelial Growth Factor Levels in Acute Coronary Syndromes2004 · 189 citations
  5. 5Physical activity in relation to indices of endothelial function and angiogenesis factors in hypertension: a substudy of the Anglo‐Scandinavian Cardiac Outcomes Trial (ASCOT)2003 · 25 citations