January 1, 2003Journal of Internal MedicineOpen Access

Physical activity in relation to indices of endothelial function and angiogenesis factors in hypertension: a substudy of the Anglo‐Scandinavian Cardiac Outcomes Trial (ASCOT)

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Why the study?

Is physical activity associated with indices of endothelial function and angiogenesis in patients with hypertension?

Population

234 patients with hypertension and 60 age and sex-matched healthy normotensive controls.

Comparison

Physical activity assessed by the Baecke… vs Low physical activity and healthy normotensive…

Design

Cross-sectional

Authors

DFD FelmedenÇevre ve Şehircilik Bakanlığı CSC. G. C. SpencerBirmingham City Hospital ABAndrew D. BlannVascular Medicine

Discussion

Member takes

Implication

No endothelial difference by activity level; leaves open mechanisms for BP and stroke benefits and requires prospective studies.

Structured PICO

Is physical activity associated with indices of endothelial function and angiogenesis in patients with hypertension?

Population

234 patients with hypertension (198 males; mean age 64 years; mean blood pressure 166/90 mmHg) and 60 age and sex-matched healthy normotensive controls.

Intervention

Physical activity assessed by the Baecke physical activity questionnaire

Comparator

Low physical activity (within hypertensive group) and healthy normotensive controls

Outcome

Indices of endothelial damage/dysfunction (flow-mediated dilatation [FMD] of the brachial artery and von Willebrand factor [vWf]) and angiogenesis (plasma vascular endothelial growth factor [VEGF] and its soluble receptor [sFlt-1])surrogate

Physical activity levels in hypertensive patients do not appear to correlate with indices of endothelial damage or angiogenesis, despite being associated with lower diastolic blood pressure and stroke risk.

Cite This Study

Felmeden et al. (2003) studied this question.

synapsesocial.com/papers/6a838597102dbb3176604feb https://doi.org/10.1046/j.1365-2796.2003.01087.x

Topics

Hypertension management Women and heart disease

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January 1, 2003Journal of Internal MedicineOpen Access

Physical activity in relation to indices of endothelial function and angiogenesis factors in hypertension: a substudy of the Anglo‐Scandinavian Cardiac Outcomes Trial (ASCOT)

View Full Paper

Ask AI

Bookmark

Why the study?

Is physical activity associated with indices of endothelial function and angiogenesis in patients with hypertension?

Population

234 patients with hypertension and 60 age and sex-matched healthy normotensive controls.

Comparison

Physical activity assessed by the Baecke… vs Low physical activity and healthy normotensive…

Design

Cross-sectional

Authors

DFD FelmedenÇevre ve Şehircilik Bakanlığı CSC. G. C. SpencerBirmingham City Hospital ABAndrew D. BlannVascular Medicine

Discussion

Member takes

Implication

No endothelial difference by activity level; leaves open mechanisms for BP and stroke benefits and requires prospective studies.

Structured PICO

Is physical activity associated with indices of endothelial function and angiogenesis in patients with hypertension?

Population

234 patients with hypertension (198 males; mean age 64 years; mean blood pressure 166/90 mmHg) and 60 age and sex-matched healthy normotensive controls.

Intervention

Physical activity assessed by the Baecke physical activity questionnaire

Comparator

Low physical activity (within hypertensive group) and healthy normotensive controls

Outcome

Cite This Study

Felmeden et al. (2003) studied this question.

synapsesocial.com/papers/6a838597102dbb3176604feb https://doi.org/10.1046/j.1365-2796.2003.01087.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Hypertension management Women and heart disease

View Full Paper

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