Why the study?
Does 42 days of 6° head-down tilted bedrest alter circadian blood pressure and systemic hemodynamics in healthy male volunteers?
Population
7 healthy male volunteers, mean age 28 years (range 25-31), non-smokers.
Comparison
42 days of 6° head-down tilted bedrest with no… vs Ambulatory baseline period.
Design
Cohort
Follow-up
42 days of head-down tilt and 2 weeks of recovery
Authors
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Prolonged head-down bedrest may blunt circadian BP variation; hypothesis-generating for orthostatic load, needs confirmation in patients.
Does 42 days of 6° head-down tilted bedrest alter circadian blood pressure and systemic hemodynamics in healthy male volunteers?
Long-term head-down tilted bedrest blunts circadian blood pressure variation, confirming the primary role of physical activity and orthostatic load in diurnal blood pressure changes.
Voogel et al. (1997) studied this question.
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