Why the study?
Does the captopril test accurately screen for renovascular hypertension in a general hypertensive population?
Does the captopril test accurately screen for renovascular hypertension in a general hypertensive population?
The captopril test demonstrates high sensitivity and specificity, making it a potentially worthwhile screening tool for renovascular hypertension in general hypertensive patients with normal renal function.
May support screening in select hypertensives; leaves open prospective validation before routine use.
The goal of this study was to determine whether the captopril test is suitable as a screening tool for renovascular hypertension (RVH) in the primary care setting. Of the 100 consecutive patients with definite hypertension included in this prospective study, three (3%) were found to have RVH. The captopril test detected RVH with a 100% sensitivity, a 90% specificity, and a 23% positive predictive value by using the three combined criteria developed by the investigators at Cornell University. We conclude that the captopril test is a worthwhile screening test for RVH in an unselected, but well prepared, general hypertensive population with normal renal function.
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Chang et al. (2005) studied this question.
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