May 1, 1971The Journal of PhysiologyOpen Access

The effects of electrical stimulation of the distal end of the cut sinus and aortic nerves on peripheral arterial chemoreceptor activity in the cat

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Why the study?

Does electrical stimulation of efferent sinus and aortic nerves reduce chemoreceptor activity in anaesthetized cats?

Population

Anaesthetized cats

Comparison

Electrical stimulation of the distal end of the… vs Baseline/no stimulation, and conditions with…

Design

Preclinical

Authors

ENE NeilUniversity of Oxford ROR. G. O’ReganUniversity College Dublin

Discussion

Member takes

Implication

Efferent stimulation may depress chemoreceptor activity in feline models; leaves open relevance to human baroreflex-chemoreflex interactions or therapies.

Structured PICO

Does electrical stimulation of efferent sinus and aortic nerves reduce chemoreceptor activity in anaesthetized cats?

Population

Anaesthetized cats

Intervention

Electrical stimulation of the distal end of the cut sinus and aortic nerves (efferent components)

Comparator

Baseline/no stimulation, and conditions with procaine, ischaemia, or atropine

Outcome

Peripheral arterial chemoreceptor activity/dischargesurrogate

Electrical stimulation of efferent sinus and aortic nerves depresses chemoreceptor activity independently of changes in glomeral blood flow in a feline model.

Cite This Study

Neil et al. (1971) studied this question.

synapsesocial.com/papers/6a70825675498292b709f3f3 https://doi.org/10.1113/jphysiol.1971.sp009455

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Implication

Efferent stimulation may depress chemoreceptor activity in feline models; leaves open relevance to human baroreflex-chemoreflex interactions or therapies.

The effects of electrical stimulation of the distal end of the cut sinus and aortic nerves on peripheral arterial chemoreceptor activity in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effects of electrical stimulation of the distal end of the cut sinus and aortic nerves on peripheral arterial chemoreceptor activity in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider