What question did this study set out to answer?

To characterize the morphological modes of glioma expansion and evaluate how microscopic invasion patterns influence clinical prognosis and surgical resectability.

January 1, 1940Brain

The Forms of Growth in Gliomas and Their Practical Significance

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Authors

HSHans-Joachim SchererUniversity of Antwerp

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Implication

Histopathological analysis demonstrates distinct glioma growth patterns in brain tissue, highlighting implications for neurosurgical resection and tumor recurrence.

Key Points

To characterize the morphological modes of glioma expansion and evaluate how microscopic invasion patterns influence clinical prognosis and surgical resectability.
Conducted extensive postmortem histopathological evaluations of cerebral glioma specimens at the Bunge Institute.
Classified primary tumor growth architectures and secondary cellular structures infiltrating pre-existing brain tissue.
Identified defined secondary structures of growth, including perivascular accumulation, perineuronal satellitosis, and subpial tumor spread.
Demonstrated that diffuse glioma cells consistently infiltrate intact brain parenchyma well beyond gross tumor margins, precluding complete surgical cure.

Cite This Study

Hans-Joachim Scherer (1940) studied this question.

synapsesocial.com/papers/6a7082a3439bab0cabc333ab https://doi.org/10.1093/brain/63.1.1

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January 1, 1940Brain

The Forms of Growth in Gliomas and Their Practical Significance

View Full Paper

Ask AI

Bookmark

Authors

HSHans-Joachim SchererUniversity of Antwerp

Discussion

Member takes

Implication

Histopathological analysis demonstrates distinct glioma growth patterns in brain tissue, highlighting implications for neurosurgical resection and tumor recurrence.

Key Points

To characterize the morphological modes of glioma expansion and evaluate how microscopic invasion patterns influence clinical prognosis and surgical resectability.
Conducted extensive postmortem histopathological evaluations of cerebral glioma specimens at the Bunge Institute.
Classified primary tumor growth architectures and secondary cellular structures infiltrating pre-existing brain tissue.
Identified defined secondary structures of growth, including perivascular accumulation, perineuronal satellitosis, and subpial tumor spread.
Demonstrated that diffuse glioma cells consistently infiltrate intact brain parenchyma well beyond gross tumor margins, precluding complete surgical cure.

Cite This Study

Hans-Joachim Scherer (1940) studied this question.

synapsesocial.com/papers/6a7082a3439bab0cabc333ab https://doi.org/10.1093/brain/63.1.1

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