United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus

Figures

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  Central Illustration. U.S. Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus ASCVD = atherosclerotic cardiovascular disease; CHD = coronary heart disease; CVD = cardiovascular disease; DM = diabetes mellitus; HF = heart failure; HDL-C = high-density lipoprotein-cholesterol; SBP = systolic blood pressure; UACR = urine albumin creatinine ratio.

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  Figure 1. Internal Calibration Plots for Each Endpoint (A) CVD; (B) ASCVD; (C) CHD; (D) HF; (E) Stroke. Points on the calibration plots represent the cumulative incidence function of observed 10-year versus mean predicted 10-year risk by different risk scores for decile groups of the predicted risk (groups with events <5 are merged with the next decile group). Calibration lines closer to the diagonal line indicate better calibration performance, with calibration slope=1 and intercept=0 being perfect calibration performance.

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  Figure 2. External Calibration Plots for CVD in Validation Cohorts (A) ARIC cohort; (B) ACCORDION cohort. Points on the calibration plots represent Kaplan-Meier observed 10-year versus mean predicted 10-year risk by different risk scores for decile groups of the predicted risk. Calibration lines closer to the diagonal line indicate better calibration performance, with calibration slope=1 being perfect calibration performance. Calibration slope <1 indicates overestimation of actual risk. GND Chi-square tests were not statistically significant, indicating excellent external calibration.