Population
Two clinically affected horses with suspected malignant hyperthermia (MHRyR1) and wild-type (WTRyR1) horses
Comparison
Genetic sequencing of the RyR1 gene and… vs Wild-type (WTRyR1) horses
Design
Preclinical
Authors
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Supports potential equine MH screening; leaves open translation to human diagnostics or therapies.
An autosomal missense mutation in the RyR1 gene is associated with malignant hyperthermia in horses, providing a potential screening test for susceptible individuals.
Aleman et al. (2004) studied this question.
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