Clinical Course and Significance of Hypertrophic Cardiomyopathy Without Left Ventricular Hypertrophy
Why the study?
Genotype-positive, LVH-negative individuals with HCM raise unresolved clinical questions regarding conversion to HCM phenotypes and the risk of cardiovascular complications.
What is the clinical course, rate of conversion to HCM phenotypes, and risk for cardiovascular complications in genotype-positive, LVH-negative individuals?
Population
Asymptomatic G+LVH- individuals with normal cardiac function from HCM families
Design
International multicenter cohort study
Authors
Discussion
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Member takes
Implication
Surveillance for conversion remains prudent in G+LVH- relatives; leaves open precise progression risks and management.
Structured PICO
What is the clinical course, rate of conversion to HCM phenotypes, and risk for cardiovascular complications in genotype-positive, LVH-negative individuals?
P
Population
Asymptomatic genotype-positive, left ventricular hypertrophy-negative (G+LVH-) family members of patients with hypertrophic cardiomyopathy, with normal cardiac function, from a large international multicenter cohort
O
Outcome
Clinical profiles, conversion to HCM phenotypes, and risk for cardiovascular complications
This study aims to define the clinical course and risk of phenotypic conversion or cardiovascular complications in asymptomatic genotype-positive, LVH-negative individuals in HCM families.
Cite This Study
Maurizi et al. (2019) studied this question.