Key result
Gene-positive HCM shows larger LA area and ~2.6x more moderate diastolic dysfunction versus hypertensive LVH.
Why the study?
There is little information regarding HCM with pathologic genetic mutations and concurrent HTN, and hypertensive LVH does not exclude an underlying genetic aetiology.
Do echocardiographic characteristics differ between genotype-positive hypertrophic cardiomyopathy and hypertensive left ventricular hypertrophy?
Population
39 adults with pathologic HCM mutations and 39 matched patients with hypertensive LVH
Comparison
Gene-positive HCM vs hypertensive LVH, and HCM with vs without concurrent HTN
Design
Single-centre case-control study
Authors
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Echocardiography can help differentiate genetic HCM from hypertensive LVH, with HCM showing more advanced diastolic dysfunction and larger left atrial size.
Case-Control (n=78)
No
Do echocardiographic characteristics differ between genotype-positive hypertrophic cardiomyopathy and hypertensive left ventricular hypertrophy?
Absolute Event Rate: 22.1% vs 18.9%
p-value: p=0.002
Echocardiography can help differentiate genetic HCM from hypertensive LVH, with HCM showing more advanced diastolic dysfunction and larger left atrial size.
Rosa et al. (2021) conducted a case-control in Hypertrophic cardiomyopathy and hypertensive left ventricular hypertrophy (n=78). Gene-positive hypertrophic cardiomyopathy vs. Hypertensive left ventricular hypertrophy was evaluated on Left atrial (LA) area (cm2) (p=0.002). Gene-positive HCM, compared to hypertensive LVH, was characterized by larger left atrial area (22.1 vs. 18.9 cm2, P=0.002) and more moderate diastolic dysfunction (33.3% vs. 12.8%, P=0.032).
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