July 1, 2004European Heart JournalOpen Access

N-Methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism

View Full Paper

Ask AI

Bookmark

Why the study?

Does N-methylethanolamine attenuate cardiac fibrosis and improve diastolic function in preclinical models of hypertensive heart failure?

Population

Human fibroblasts and a hypertensive heart failure model using Dahl-Iwai salt-sensitive rats

Design

Preclinical

Authors

Discussion

MEA attenuates fibrosis in hypertensive heart failure models; hypothesis-generating for human phospholipase D inhibition trials.

Does N-methylethanolamine attenuate cardiac fibrosis and improve diastolic function in preclinical models of hypertensive heart failure?

Population

Human fibroblasts and a hypertensive heart failure model using Dahl-Iwai salt-sensitive rats

Intervention

N-methylethanolamine (MEA)

Outcome

Phospholipase D (PLD) activity, collagen synthesis, and collagenase productionsurrogate

N-methylethanolamine may offer a therapeutic approach for cardiac disorders involving ventricular fibrosis by suppressing phospholipase D activity.

Kōichi Yamamoto (2004) studied this question.

View Full Paper

Ask AI

Bookmark