Key result
Angiotensin II blockade, but not calcineurin inhibition, prevented progressive collagen accumulation and myocardial stiffening in pressure-overloaded rat hearts, independent of LV hypertrophy.
Why the study?
Does angiotensin II type 1 receptor antagonism or calcineurin inhibition prevent myocardial stiffening in pressure-overloaded rat hearts?
Population
20 Dahl-Iwai salt-sensitive rats fed on high-salt diet since 7 weeks
Comparison
Angiotensin II type 1 receptor antagonist or… vs Untreated rats (n=7)
Design
Preclinical
Follow-up
12 weeks (from 8 weeks to 20 weeks of age)
Authors
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Hypothesis-generating for Ang II blockade in overload fibrosis; prospective human studies needed before adoption.
Does angiotensin II type 1 receptor antagonism or calcineurin inhibition prevent myocardial stiffening in pressure-overloaded rat hearts?
Myocardial stiffening in pressure-overloaded hearts is driven by progressive collagen accumulation and cross-linking rather than compensatory or excessive LV hypertrophy.
Kazuhiro Yamamoto (2002) studied Hypertensive heart disease (n=20). Angiotensin II type 1 receptor antagonist or calcineurin inhibitor vs. Untreated rats was evaluated on Myocardial stiffness, LV hypertrophy, and fibrosis markers (hydroxyproline content, collagen mRNA ratio, collagen solubility). Angiotensin II blockade, but not calcineurin inhibition, prevented progressive collagen accumulation and myocardial stiffening in pressure-overloaded rat hearts, independent of LV hypertrophy.
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