Population
Bovine aortic endothelial cells and bovine eNOS protein (in vitro and in vivo models)
Comparison
Protein kinase C phosphorylation vs Unphosphorylated state / untreated cells
Design
Preclinical
Authors
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Alerts to PKC-eNOS axis in vascular disease; leaves open translation from animal models to human therapies.
Protein kinase C negatively regulates endothelial nitric oxide synthase activity by phosphorylating Thr497, which reduces the enzyme's affinity for its activator, calmodulin.
Mamoru Matsubara (2003) studied this question.
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