Shows how epithelial tissue modulates smooth muscle contraction via prostaglandins across organ systems, highlighting critical mechanisms in physiology and disease.
As an analog to the endothelium situated next to the vascular smooth muscle, the epithelium is emerging as an important regulator of smooth muscle contraction in many vital organs/tissues by interacting with other cell types and releasing epithelium-derived factors, among which prostaglandins have been demonstrated to play a versatile role in governing smooth muscle contraction essential to the physiological and pathophysiological processes in a wide range of organ systems.
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Ruan et al. (2011) studied this question.
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