January 1, 1979Journal of Biological ChemistryOpen Access

Purification and characterization of an inhibitor protein of brain adenylate cyclase and cyclic nucleotide phosphodiesterase.

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Population

Bovine brain cerebrum

Design

Preclinical

Authors

RWRobert W. WallaceOur Lady of the Lake Regional Medical Center TLThomas J. LynchGenVec ETE. Ann TallantWake Forest University

Discussion

Member takes

Implication

Identifies a Ca2+-dependent regulator of cyclic nucleotide enzymes; leaves open its relevance to cardiac signaling or therapeutic targeting.

Structured PICO

Population

Bovine brain cerebrum

Intervention

Purification and characterization of a heat-labile inhibitor protein of adenylate cyclase and phosphodiesterase

Outcome

Characteristics and mechanism of action of the inhibitor protein

The study identifies and characterizes a heat-labile inhibitor protein from bovine brain that regulates adenylate cyclase and phosphodiesterase by competing for their Ca2+-dependent activator protein.

Cite This Study

Wallace et al. (1979) studied this question.

synapsesocial.com/papers/6a7085ca660549caf2c51fac https://doi.org/10.1016/s0021-9258(17)37928-0

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Implication

Identifies a Ca2+-dependent regulator of cyclic nucleotide enzymes; leaves open its relevance to cardiac signaling or therapeutic targeting.

Purification and characterization of an inhibitor protein of brain adenylate cyclase and cyclic nucleotide phosphodiesterase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Purification and characterization of an inhibitor protein of brain adenylate cyclase and cyclic nucleotide phosphodiesterase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider