November 10, 2011The Journals of Gerontology Series A

Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging

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Why the study?

Does GH/IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese rats?

Population

GH/IGF-1-deficient Lewis dwarf rats and heterozygous control rats

Comparison

High-fat diet (HFD) for 7 months vs Standard diet for 7 months

Design

Preclinical

Follow-up

7 months

Authors

LBLora C. Bailey‐DownsUniversity of Oklahoma Health Sciences Center DSDanuta SosnowskaUniversity of Geneva PTPéter TóthSemmelweis University

Discussion

Member takes

Implication

Hypothesis-generating for GH/IGF-1 protection against obesity-related vascular damage in aging; human studies required before any clinical translation.

Structured PICO

Does GH/IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese rats?

Population

GH/IGF-1-deficient Lewis dwarf rats and heterozygous control rats

Intervention

High-fat diet (HFD) for 7 months

Comparator

Standard diet for 7 months

Outcome

Endothelial dysfunction, oxidative stress, and expression of inflammatory markers (tumor necrosis factor-α, ICAM-1) in aortassurrogate

GH/IGF-1 deficiency exacerbates high-fat diet-induced inflammation, oxidative stress, and endothelial dysfunction in a rat model, suggesting a mechanism for increased cardiovascular vulnerability in obese elderly individuals.

Cite This Study

Bailey‐Downs et al. (2011) studied this question.

synapsesocial.com/papers/6a70873cf44fa9f079de3113 https://doi.org/10.1093/gerona/glr197

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Implication

Hypothesis-generating for GH/IGF-1 protection against obesity-related vascular damage in aging; human studies required before any clinical translation.

Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider