Key result
Epicardial fat thickness is not associated with conduction disorders or paravalvular regurgitation after TAVI.
Why the study?
Chronic inflammation promotes aortic valve calcification and epicardial fat is a source of inflammation, prompting investigation into whether epicardial fat thickness relates to cardiac conduction disorders and outcomes after TAVI.
Does pre-procedural epicardial fat thickness measured by multi-slice computed tomography predict cardiac conduction disorders and post-procedural outcomes in patients with severe aortic stenosis undergoing TAVI?
Cohort (n=45)
No
Does pre-procedural epicardial fat thickness measured by multi-slice computed tomography predict cardiac conduction disorders and post-procedural outcomes in patients with severe aortic stenosis undergoing TAVI?
Pre-procedural epicardial fat thickness measured on multi-slice CT did not predict post-procedural conduction abnormalities, pacemaker requirement, or paravalvular regurgitation in patients undergoing TAVI, though larger studies are needed.
Answers are grounded in this paper and cite their sources.
Does not support epicardial fat thickness for pre-TAVI risk stratification; leaves open identification of conduction and regurgitation predictors in larger cohorts.
INTRODUCTION Chronic inflammation promotes aortic valve calcification. It is known that epicardial fat is a source of inflammation. The aim of this study was to investigate the relationship between epicardial fat thickness, cardiac conduction disorders and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS During a three-year period, 45 patients with severe aortic stenosis who underwent TAVI were recruited to the study. Data were collected retrospectively. Epicardial fat was defined as the adipose tissue between the epicardium and the visceral pericardium. Mean epicardial fat thickness was determined by multi-slice computed tomography, which was performed before the procedure. RESULTS The average thickness of epicardial fat was 13.06 ± 3.29 mm. This study failed to reveal a significant correlation between epicardial fat thickness and post-procedural left bundle branch block, right bundle branch block, paravalvular aortic regurgitation and pacemaker implantation rates (p > 0.05). CONCLUSIONS The results of this study failed to show a significant relationship between epicardial fat thickness, cardiac conduction disorders and outcomes, however further studies with larger sample numbers are required to explore the relationship.
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Ertaş et al. (2022) conducted a cohort in Severe symptomatic calcific aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) (n=45). Pre-procedural epicardial fat thickness assessed by multi-slice computed tomography was evaluated on Association of epicardial fat thickness with post-procedural cardiac conduction disorders (LBBB, RBBB, pacemaker implantation) and paravalvular aortic regurgitation (p=>0.05). Pre-procedural epicardial fat thickness (mean 13.06 ± 3.29 mm) was not significantly associated with post-TAVI LBBB, RBBB, paravalvular aortic regurgitation, or pacemaker implantation (p > 0.05).
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