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May 20, 2019UltrasoundOpen Access

Epicardial adipose tissue and its association with cardiovascular risk factors and mitral annular calcium deposits

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Why the study?

Epicardial fat secretes pro-inflammatory cytokines that can promote atherosclerosis, and cardiovascular risk factors correlate with mitral annular calcification severity, motivating assessment of the correlation between epicardial fat thickness and mitral annular calcification.

Does increased epicardial fat thickness correlate with mitral annular calcification in patients undergoing coronary angiography?

Population

188 patients considered for coronary angiography who underwent echocardiography within 24 hours of admission

Comparison

Epicardial fat thickness ≥7 mm vs <7 mm

Design

Observational echocardiographic study

Authors

MNMaryam NabatiUniversity of MazandaranASAlireza SalehiShiraz University of Medical SciencesGHGhazal HatamiMazandaran University of Medical Sciences

Discussion

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Implication

Epicardial fat thickness was associated with mitral annular calcification; leaves open whether this informs risk stratification or warrants intervention.

Structured PICO

Does increased epicardial fat thickness correlate with mitral annular calcification in patients undergoing coronary angiography?

P
Population
188 patients (96 males, 92 females) considered for coronary angiography, excluding those with STEMI, significant primary valvular heart disease, or chronic kidney disease.
I
Intervention
Epicardial fat thickness ≥ 7 mm measured by transthoracic echocardiography
C
Comparator
Epicardial fat thickness < 7 mm
O
Outcome
Prevalence and severity of mitral annular calcification (MAC)surrogate

Increased epicardial fat thickness (≥7 mm) is significantly associated with a higher prevalence of mitral annular calcification and more complex coronary artery disease in patients undergoing coronary angiography.

Limitations

  • small sample size from a single center
  • retrospective cohort study which the patients' clinical outcomes or mortality were not included
  • all patients included were suspected of having CAD (selection bias)

Cite This Study

Nabati et al. (2019) studied this question.

synapsesocial.com/papers/6a70c5815671bbf00bc2c480https://doi.org/10.1177/1742271x19846159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epicardial Fat: Definition, Measurements and Systematic Review of Main Outcomes2013 · 267 citations
  2. 2Mitral annular calcification: a marker of severe coronary artery disease in patients under 65 years old2003 · 115 citations
  3. 3Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study2008 · 50 citations
  4. 4Left atrial size and risk for all-cause mortality and ischemic stroke2011 · 172 citations
  5. 5Family history of coronary artery disease — need to focus on proper definition!2003 · 24 citations