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Highlights new mechanisms by which aldosterone directly affects the vasculature through mineralocorticoid receptors, influencing myogenic tone and blood pressure in aging.
E ffects of aldosterone on blood pressure control have classically been attributed to sodium retention through its action on the kidney. However, increasingly it has been appreciated that aldosterone exerts effects directly on the vasculature. Here, we comment on novel data published recently that sheds light on new mechanisms, whereby aldosterone acting through the mineralocorticoid receptor on blood vessels, in interaction with angiotensin II and via oxidative stress and calcium channels, may affect age-associated changes in myogenic tone and exert effects on blood pressure regulation.
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Ernesto L. Schiffrin (2013) studied this question.
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