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January 6, 2012ObesityOpen Access

Intra‐Abdominal Adipose Tissue Is Independently Associated With Sex‐Hormone Binding Globulin in Premenopausal Women

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Why the study?

Does weight loss-induced reduction in intra-abdominal adipose tissue increase sex-hormone binding globulin in overweight premenopausal women?

Population

107 overweight (BMI 27-30 kg/m2) premenopausal women enrolled in a weight loss study

Comparison

Weight loss until BMI of ≤ 24 kg/m2 was achieved vs Baseline (pre-weight loss)

Design

Cohort

Authors

MAMaria AzradUniversity of AlabamaBGBarbara A. GowerUniversity of Alabama at BirminghamGHGary R. HunterUniversity of Alabama at Birmingham

Discussion

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Implication

IAAT may inversely influence SHBG independent of insulin after weight loss; hypothesis-generating for visceral fat reduction in overweight premenopausal women.

Structured PICO

Does weight loss-induced reduction in intra-abdominal adipose tissue increase sex-hormone binding globulin in overweight premenopausal women?

P
Population
107 overweight (BMI 27-30 kg/m2) premenopausal women enrolled in a weight loss study
I
Intervention
Weight loss until BMI of ≤ 24 kg/m2 was achieved
C
Comparator
Baseline (pre-weight loss)
O
Outcome
Longitudinal association between intra-abdominal adipose tissue (IAAT) and sex-hormone binding globulin (SHBG)surrogate

In overweight premenopausal women, sex-hormone binding globulin concentrations are inversely influenced by intra-abdominal adipose tissue rather than insulin levels.

Cite This Study

Azrad et al. (2012) studied this question.

synapsesocial.com/papers/6a708ab626a7f98052dd07b0https://doi.org/10.1038/oby.2011.375
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial Differences in the Association Between Sex Hormone–Binding Globulin and Adiposity in Premenopausal Women2010 · 12 citations
  2. 2Sex hormone-binding globulin levels in middle-aged premenopausal women. Associations with visceral obesity and metabolic profile.1999 · 79 citations
  3. 3Case--Control Study of Endogenous Steroid Hormones and Endometrial Cancer1996 · 298 citations
  4. 4Exercise Training Prevents Regain of Visceral Fat for 1 Year Following Weight Loss2009 · 137 citations
  5. 5Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men.1993 · 167 citations