What question did this study set out to answer?

To evaluate whether histologic features and proliferation markers in core needle biopsy specimens of fibroepithelial lesions with cellular stroma can reliably distinguish fibroadenomas from phyllodes tumors.

September 1, 2005American Journal of Clinical Pathology

Fibroepithelial Lesions With Cellular Stroma on Breast Core Needle Biopsy

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Authors

TJTimothy W. JacobsJacobs (United States)YCYunn‐Yi ChenUniversity of Vermont DGDonald G. GuineeVirginia Mason Medical Center

Discussion

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Implication

Blinded pathology study reveals that stromal cellularity, mitoses, and proliferation indices differentiate phyllodes tumors from fibroadenomas, highlighting markers to guide surgical excision.

Key Points

To evaluate whether histologic features and proliferation markers in core needle biopsy specimens of fibroepithelial lesions with cellular stroma can reliably distinguish fibroadenomas from phyllodes tumors.
Blinded evaluation of 29 core needle biopsy specimens diagnosed with fibroepithelial lesions with cellular stroma correlated against definitive excision pathology.
Histologic assessment of stromal cellularity and mitoses combined with immunohistochemical evaluation of p53 expression and proliferation indices using Ki-67 and topoisomerase II α.
Surgical excision confirmed 16 fibroadenomas and 12 phyllodes tumors; all biopsies with mildly increased cellularity (n = 4) were fibroadenomas, and all with markedly cellular stroma (n = 4) were phyllodes tumors.
Among 20 biopsy specimens with moderate cellularity (12 fibroadenomas and 8 phyllodes tumors), only stromal mitoses provided histological discrimination.
Stromal proliferation indices (Ki-67 and topoisomerase II α) were significantly higher in core needle biopsies that proved to be phyllodes tumors compared to fibroadenomas.

Cite This Study

Jacobs et al. (2005) studied this question.

synapsesocial.com/papers/6a708b6026770c2b8de09891 https://doi.org/10.1309/5n2c4n5xcb8xw8jl

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Implication

Blinded pathology study reveals that stromal cellularity, mitoses, and proliferation indices differentiate phyllodes tumors from fibroadenomas, highlighting markers to guide surgical excision.

Fibroepithelial Lesions With Cellular Stroma on Breast Core Needle Biopsy

Discussion

Member takes

Implication

Key Points

Cite This Study

Fibroepithelial Lesions With Cellular Stroma on Breast Core Needle Biopsy

Discussion

Member takes

Implication

Key Points

Cite This Study

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