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January 1, 2023Proceedings for Annual Meeting of The Japanese Pharmacological SocietyOpen Access

Induction of cancer cell-specific cell death by novel cyclic naphthalene diimide derivatives

Yaida Noboru Sen Higashi Hikaru Fukuda Manabu Habu Masaaki Sasaguri Shinobu Satoh Shigeori Takenaka Hiroshi Takeuchi

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Abstract

Recently, it became clear that guanine-rich DNA sequences could form characteristic four-stranded structure (G4). As G4 is frequently found in chromosomal telomere regions and in the promotor region of cancer-related genes, G4 is expected to be a target for developing new anticancer drugs. In this study, we compared cytotoxic effect of cyclic naphthalenediimide derivative (cNDI) that specifically bind to G4, with a widely-used anticancer drug cisplatin (CDDP).

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Cite This Study

Noboru et al. (2023) studied this question.

synapsesocial.com/papers/6a708c2c75498292b709fdc7 https://doi.org/10.1254/jpssuppl.97.0_3-b-p-065

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