Why the study?
Does allograft aortic valve replacement provide comparable durability and freedom from reoperation compared to porcine and pericardial bioprostheses in patients requiring AVR?
Population
336 patients undergoing allograft aortic valve or root replacement, mean age 45 years, 72% male. Etiologies…
Comparison
Allograft aortic valve or root replacement vs Porcine and pericardial bioprostheses
Design
Cohort
Follow-up
mean 7.4 years, maximum 18.5 years
Authors
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Comparable reoperation risk to xenografts supports allograft consideration in AVR; extends observational durability data but leaves open need for randomized trials.
Does allograft aortic valve replacement provide comparable durability and freedom from reoperation compared to porcine and pericardial bioprostheses in patients requiring AVR?
Allografts for aortic valve replacement offer low rates of early valve-related events, but the risk of structural valve deterioration increases over time and is comparable to stented xenografts.
Takkenberg et al. (2007) studied this question.
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