What question did this study set out to answer?

To review the mechanisms by which the bone microenvironment regulates cancer cell seeding, dormancy, and metastatic outgrowth.

November 26, 2018Journal of Bone and Mineral ResearchOpen Access

Understanding the Bone in Cancer Metastasis

View Full Paper

Ask AI

Bookmark

Authors

JFJaime FornettiHuntsman Cancer Institute AWAlana L. WelmHuntsman Cancer Institute SSSheila A. StewartWashington University in St. Louis

Discussion

Member takes

Implication

Review highlights the role of the bone microenvironment in tumor seeding and dormancy, suggesting niche-specific targets may prevent metastatic cancer progression.

Key Points

To review the mechanisms by which the bone microenvironment regulates cancer cell seeding, dormancy, and metastatic outgrowth.
Reviewed historical and current literature on the 'seed and soil' hypothesis of cancer metastasis.
Synthesized molecular and cellular evidence regarding bone niche components, including the endosteal niche, osteoclasts, osteocytes, and adipocytes.
The endosteal niche plays a critical role in inducing and maintaining tumor cell dormancy within the bone.
Interactions with bone resident cells, such as osteoclasts, osteocytes, and adipocytes, drive metastatic tumor reactivation and colonization.
Bone metastasis causes significant patient morbidity, including severe bone pain, increased risk of skeletal fractures, and hypercalcemia.

Cite This Study

Fornetti et al. (2018) studied this question.

synapsesocial.com/papers/6a708e11b27f1581782768df https://doi.org/10.1002/jbmr.3618

View Full Paper

Ask AI

Bookmark

Implication

Review highlights the role of the bone microenvironment in tumor seeding and dormancy, suggesting niche-specific targets may prevent metastatic cancer progression.

Understanding the Bone in Cancer Metastasis

Discussion

Member takes

Implication

Key Points

Cite This Study

Understanding the Bone in Cancer Metastasis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider