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Dr. Trevino (1) has derived a mathematical formula for HbA1c (A1C) change in response to exponential plasma glucose decay. His analysis has shown a faster decay of A1C associated with a slower decay of plasma glucose and posed a question to the weighted-average relationship between plasma glucose and A1C, which we proposed in our previous study (2). Since his derived formula is very complicated and the detailed analytical method is not given, I cannot exactly reply to his question. However, I propose here a new physiological model, which deals with the …
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Yasuhiro Tahara (2006) studied this question.
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