Why the study?
Does a higher dose concentration of adriamycin increase the risk of cardiotoxicity and reduced cardiac function in children treated for Ewing sarcoma compared to soft tissue sarcoma?
Population
56 children treated for sarcoma at B.C.'s Children's Hospital between 1978 and 1991, including 30 with Ewing…
Comparison
Ewing sarcoma chemotherapy regimen vs Soft tissue sarcoma chemotherapy regimen
Design
Cohort
Authors
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Warrants vigilant cardiac monitoring in Ewing sarcoma; leaves open whether adriamycin dose concentration drives differential cardiotoxicity.
Does a higher dose concentration of adriamycin increase the risk of cardiotoxicity and reduced cardiac function in children treated for Ewing sarcoma compared to soft tissue sarcoma?
Higher dose concentrations of adriamycin in Ewing sarcoma treatment are associated with a significantly increased risk of severe cardiotoxicity and reduced shortening fraction compared to soft tissue sarcoma regimens.
Kakadekar et al. (1997) studied this question.
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