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June 1, 1969The Journal of General PhysiologyOpen Access

Parallel Response of Myofibrillar Contraction and Relaxation to Four Different Nucleoside Triphosphates

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Population

Myofibrils

Comparison

Mg chelates of ITP, GTP, and UTP vs Mg chelate of ATP

Design

Preclinical

Authors

AWA. WeberPázmány Péter Catholic University

Discussion

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Implication

Does not support clinical translation; leaves open nucleotide-specific roles in human myofibrillar regulation pending in vivo studies.

Structured PICO

P
Population
Myofibrils
I
Intervention
Mg chelates of ITP, GTP, and UTP
C
Comparator
Mg chelate of ATP
O
Outcome
Myofibrillar contraction and relaxation (measured by inhibition of syneresis and reduction of NTPase activity)surrogate

The study demonstrates that myofibrillar relaxation depends on the saturation of the hydrolytic site with nucleoside triphosphates rather than binding to a special inhibitory site.

Cite This Study

A. Weber (1969) studied this question.

synapsesocial.com/papers/6a708f2178a11c550e0a7dechttps://doi.org/10.1085/jgp.53.6.781
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1On the Mechanism of the Relaxing Effect of Fragmented Sarcoplasmic Reticulum1963 · 233 citations
  2. 2The estimation of creatine and of diacetyl1943 · 257 citations
  3. 3Troponin as the Ca++-receptive Protein in the Contractile System*1967 · 166 citations