Demonstrates that rabbit tropomyosin exhibits polymorphism (fibers vs lattices) dependent on divalent cation concentration and pH, with implications for striated and smooth muscle morphology.
No clinical implications yet; leaves open cation-driven tropomyosin polymorphism in muscle architecture.
Rabbit tropomyosin exhibits a polymorphism dependent on divalent cations and pH. Above a critical divalent cation concentration fibers with a period of about 400 angstroms are formed. Below this concentration, and near the isoelectric point, lattices are formed. Implications for the morphology and function of striated and smooth muscle are discussed.
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Cohen et al. (1966) studied this question.
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