pH-dependent structural transition in rabbit skeletal troponin C.
Population
Rabbit skeletal troponin C
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Troponin C pH sensitivity should not change practice; hypothesis-generating for acidosis effects on cardiac contractility.
Structured PICO
P
Population
Rabbit skeletal troponin C
I
Intervention
Varying pH conditions (pH 5.0 and pH 6.8) and complexation with troponin I
O
Outcome
Distance between sites located in the N- and C-terminal domains measured by resonance energy transfersurrogate
Uncomplexed troponin C undergoes a pH-dependent transition from an elongated conformation at acidic pH to a more compact conformation at neutral pH.
Cite This Study
Wang et al. (1987) studied this question.