November 21, 2000Biochemistry

Proximity Relationships between Residue 6 of Troponin I and Residues in Troponin C: Further Evidence for Extended Conformation of Troponin C in the Troponin Complex

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Population

Skeletal muscle troponin C and troponin I complexes

Design

Preclinical

Authors

YLYin LuoFudan University JLJohn LeszykUniversity of Massachusetts Chan Medical School BLBing LiUniversity of Cambridge

Discussion

Member takes

Implication

Preclinical skeletal data support extended TnC conformation; leaves open cardiac isoform relevance and in vivo validation.

Structured PICO

Population

Skeletal muscle troponin C (TnC) and troponin I (TnI) complexes (intact troponin complex and binary TnC.TnI complex)

Intervention

Attachment of fluorescence and photo-cross-linking probes to a mutant TnI with a single cysteine at residue 6

Outcome

Distances from TnI residue 6 to residues of TnC and sites of photo-cross-linking in TnCsurrogate

The study provides evidence that skeletal muscle troponin C adopts an extended conformation in the intact troponin complex, emphasizing the structural role of the N-terminal region of troponin I.

Cite This Study

Luo et al. (2000) studied this question.

synapsesocial.com/papers/6a906b329f954bcfeb909ee3 https://doi.org/10.1021/bi001259x

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Proximity Relationships between Residue 6 of Troponin I and Residues in Troponin C: Further Evidence for Extended Conformation of Troponin C in the Troponin Complex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Proximity Relationships between Residue 6 of Troponin I and Residues in Troponin C: Further Evidence for Extended Conformation of Troponin C in the Troponin Complex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider