Population
Rabbit skeletal muscle troponin C, bovine cardiac troponin C, and bovine brain calmodulin
Comparison
Exposure to acidic pH (pH 5.2) vs Exposure to neutral pH (pH 7.5)
Design
Preclinical
Authors
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Acidic pH induces skeletal but not cardiac troponin C dimerization in vitro; leaves open relevance to human cardiac acidosis or disease.
Acidic pH induces dimerization and an extended conformation in skeletal troponin C, driven by hydrophobic bonding, a property not shared by cardiac troponin C.
Wang et al. (1989) studied this question.
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