Population
Rabbit skeletal troponin C and its complex with troponin I
Comparison
Ca2+ binding and pH alteration vs Mg2+ binding and neutral pH (7.5)
Design
Preclinical
Authors
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May alter troponin C conformation during acidosis; leaves open functional impact on muscle contractility in vivo.
The study demonstrates that Ca2+ binding and pH changes significantly alter the conformation of skeletal troponin C, which may play a role in muscle signaling.
Cheung et al. (1991) studied this question.
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