Key result
cTnC shows no gross conformational alteration during cardiac muscle activation.
Population
Cardiac muscle troponin C (cTnC) with a single-tryptophan mutant
Design
Preclinical
Authors
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Indicates cTnC activation without gross conformational change in animals; leaves open whether subtle dynamics drive human thin-filament regulation.
The transition from the relaxed state to an activated state in cardiac muscle is not accompanied by a gross alteration of the cTnC conformation in cardiac troponin.
Dong et al. (2000) studied this question. The mean interdomain distance in cardiac troponin C was 48-49 A, indicating that the transition to an activated state in cardiac muscle is not accompanied by a gross alteration of cTnC conformation.
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