Population
Reconstituted functional, ternary troponin complexes using recombinant subunits based on rabbit skeletal…
Comparison
Exposure to Ca2+, Mg2+, or EGTA vs Comparison between relaxed state and Ca2+-bound…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open troponin flexibility as a therapeutic target in human cardiac disease.
This study provides the first distance distribution measurements between troponin subunits, revealing that calcium binding induces significant flexibility in the troponin complex to facilitate muscle contraction.
Zhao et al. (1995) studied this question.
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