Population
Calcium-saturated skeletal muscle troponin C (TnC)
Comparison
3D and 4D heteronuclear nuclear magnetic… vs Half-saturated form determined by X-ray methods
Design
Preclinical
Authors
Loading...
May inform troponin-targeted drug design; leaves open translation to human cardiac therapies.
The NMR solution structure of calcium-saturated skeletal muscle troponin C reveals a flexible linker between domains and an open hydrophobic pocket in the N-terminal domain for target interaction.
Slupsky et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: