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October 1, 2002Journal of Biological ChemistryOpen Access

Solution Structure of Calcium-saturated Cardiac Troponin C Bound to Cardiac Troponin I

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Authors

ADAlex DvoretskyOles Honchar Dnipro National University EAEkram AbusamhadnehLos Alamos National Laboratory JHJack W. HowarthUniversity of Cincinnati Medical Center

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Implication

Structural insights into TnC-cTnI binding may guide future troponin modulators; leaves open clinical translation pending functional studies.

Key Points

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Cite This Study

Dvoretsky et al. (2002) studied this question.

synapsesocial.com/papers/6a83d8e7a3cef8348e9975d0 https://doi.org/10.1074/jbc.m205306200

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cardiac Troponin I Induced Conformational Changes in Cardiac Troponin C As Monitored by NMR Using Site-Directed Spin and Isotope Labeling1995 · 51 citations
2Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings2000 · 23 citations
3Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I,1999 · 53 citations
4An interdomain distance in cardiac troponin c determined by fluorescence spectroscopy2000 · 22 citations
5Modulation of Cardiac Troponin C−Cardiac Troponin I Regulatory Interactions by the Amino-terminus of Cardiac Troponin I2001 · 46 citations