Population
Cardiac troponin C (cNTnC) samples dissolved in dilute liquid crystals
Comparison
Complexation with the second binding region of… vs apo-cNTnC (uncomplexed/unloaded)
Design
Preclinical
Authors
Loading...
Reinforces cTnC Ca2+-switch model at residue level; leaves open validation in cellular and in vivo cardiac systems.
The study provides structural evidence that cardiac troponin C functions as a calcium-dependent open-closed switch upon interaction with troponin I.
Pääkkönen et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: