Why the study?
Does treatment with aminophylline and isoproterenol improve spinal cord blood flow in cats with impact spinal cord injury?
Population
Cats with spinal cord injury (400 mg-cm impact)
Comparison
Aminophylline and isoproterenol vs Control (untreated injured cats)
Design
Preclinical
Authors
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Does not support clinical use in spinal cord injury; leaves open translation of aminophylline-isoproterenol effects to human trials.
Does treatment with aminophylline and isoproterenol improve spinal cord blood flow in cats with impact spinal cord injury?
Aminophylline and isoproterenol improve spinal cord blood flow following impact injury in a feline model, possibly by preventing platelet aggregation.
Dow-Edwards et al. (1980) studied this question.
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