Why the study?
Picornaviral IRES elements are essential for initiating cap-independent viral translation, but their three-dimensional structures remain elusive.
The crystal structure of HAV IRES domain V reveals a conserved topological strategy for organizing the domain architecture among picornaviral IRESs.
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Reveals three-way junction architecture of HAV IRES dV; leaves open its role in cap-independent translation across picornaviruses.
Koirala et al. (2019) studied this question.
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