What question did this study set out to answer?

To evaluate the associations between prediagnostic circulating concentrations of sex hormones and subsequent breast cancer risk in premenopausal women.

July 24, 2013The Lancet OncologyOpen Access

Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies

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Discussion

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Implication

Pooled analysis of prospective studies reveals elevated circulating oestrogens and androgens increase breast cancer risk in premenopausal women, highlighting endocrine biomarkers for risk.

Key Points

To evaluate the associations between prediagnostic circulating concentrations of sex hormones and subsequent breast cancer risk in premenopausal women.
Pooled individual participant data from seven prospective studies comprising up to 767 premenopausal breast cancer cases and 1699 matched controls younger than 50 years at blood collection.
Estimated odds ratios (ORs) per doubling of hormone concentrations using conditional logistic regression matched for age, blood collection date, and cycle day, with adjustment for cycle phase.
Breast cancer risk increased significantly with a doubling in concentrations of oestradiol (OR 1.19, 95% CI 1.06–1.35), calculated free oestradiol (OR 1.17, 95% CI 1.03–1.33), oestrone (OR 1.27, 95% CI 1.05–1.54), androstenedione (OR 1.30, 95% CI 1.10–1.55), DHEAS (OR 1.17, 95% CI 1.04–1.32), and testosterone (OR 1.18, 95% CI 1.03–1.35).
No association was observed for calculated free testosterone (OR 1.08, 95% CI 0.97–1.21) or luteal phase progesterone (OR 1.00, 95% CI 0.92–1.09).

Cite This Study

† (2013) studied this question.

synapsesocial.com/papers/6a708fe975498292b70a022d https://doi.org/10.1016/s1470-2045(13)70301-2

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July 24, 2013The Lancet OncologyOpen Access

Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies

View Full Paper

Ask AI

Bookmark

Authors

††

Discussion

Member takes

Implication

Pooled analysis of prospective studies reveals elevated circulating oestrogens and androgens increase breast cancer risk in premenopausal women, highlighting endocrine biomarkers for risk.

Key Points

To evaluate the associations between prediagnostic circulating concentrations of sex hormones and subsequent breast cancer risk in premenopausal women.
Pooled individual participant data from seven prospective studies comprising up to 767 premenopausal breast cancer cases and 1699 matched controls younger than 50 years at blood collection.
Estimated odds ratios (ORs) per doubling of hormone concentrations using conditional logistic regression matched for age, blood collection date, and cycle day, with adjustment for cycle phase.
Breast cancer risk increased significantly with a doubling in concentrations of oestradiol (OR 1.19, 95% CI 1.06–1.35), calculated free oestradiol (OR 1.17, 95% CI 1.03–1.33), oestrone (OR 1.27, 95% CI 1.05–1.54), androstenedione (OR 1.30, 95% CI 1.10–1.55), DHEAS (OR 1.17, 95% CI 1.04–1.32), and testosterone (OR 1.18, 95% CI 1.03–1.35).
No association was observed for calculated free testosterone (OR 1.08, 95% CI 0.97–1.21) or luteal phase progesterone (OR 1.00, 95% CI 0.92–1.09).

Cite This Study

† (2013) studied this question.

synapsesocial.com/papers/6a708fe975498292b70a022d https://doi.org/10.1016/s1470-2045(13)70301-2

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