Why the study?
HIV-infected patients have an increased tendency to CVD, and arterial inflammation plays an important role in atherogenesis and CVD risk.
Does F-18 FDG PET/CT effectively image arterial inflammation in HIV-infected patients with vascular atherosclerosis?
Does F-18 FDG PET/CT effectively image arterial inflammation in HIV-infected patients with vascular atherosclerosis?
F-18 FDG PET/CT and emerging novel ligands have significant potential for visualizing arterial inflammation and assessing cardiovascular risk in HIV-infected patients.
FDG PET/CT may best image arterial inflammation in HIV-CVD; leaves open routine adoption pending prospective validation.
The review examined the role of arterial inflammation in atherogenesis and the pathogenic factors responsible for the high risk of cardiovascular diseases (CVD) among HIV-infected patients. Inflammation has been shown to play an important role in all phases of atherosclerotic CVD. HIV-infected patients have an increased tendency to CVD. The most effective radionuclide method of imaging the inflammatory process in the pathogenesis of CVD among HIV-infected people is F-18 FDG PET/CT. At the present stage, several ligands for visualization were synthesized, which were used to identify vascular inflammation in preclinical and clinical studies. These tracers, in addition to F-18 FDG, have significant potential for future use among HIV-infected patients.
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Korol et al. (2019) studied this question.
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