Proteins of Middle Ear Secretion in Serous Otitis an Electrophoretic and Immunoelectrophoretic Study

The protein fractions of the middle ear secretions of 22 patients with true serous otitis were studied electrophoretically and immunoelectrophoretically. The total protein of the secretion varied from 0.4 to 10.5g/100cc, mean 4.5g/100cc. The electrophoretic protein pattern of the secretion was mostly similar to that of the serum. The relative albumin content seemed to be a little lower and that of gamma globulin a little higher than in serum. A very small amount or no γM immunoglobulin was present in the secretion, while γA was clearly demonstrable in little more than half of the cases.