Functionalized Organoimidorhenium(V) Complexes as Potential Radiopharmaceuticals: Syntheses of Glycine Derivatives and the Structure Determination of a Rhenium Analogue of Chlorambucil

Two important aspects, the synthesis of imido complexes of radioactive metal isotopes and the diversity that can be incorporated with this ligand, distinguish this communication. The multiply bonded organoimide ligand provides a new and powerful means of conjugating suitable radioisotopes of rhenium to biologically relevant molecules in the design of radiopharmaceuticals. Here stable isotope and 188Re-labeled analogues (1) of the anticancer drug chlorambucil were synthesized.