Why the study?
Does levosimendan better maintain postoperative cardiac function compared to milrinone in patients with severely compromised ventricular function undergoing elective cardiac surgery?
Population
30 patients with a preoperative ejection fraction ≤30% scheduled for elective cardiac surgery with…
Comparison
Levosimendan 0.1 μg/kg/min started immediately… vs Milrinone 0.5 μg/kg/min started immediately…
Design
RCT, Randomized to two different inotropic protocols, Treatment was masked to…
Follow-up
Up to 30 days
Authors
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Levosimendan may be preferred over milrinone to preserve postoperative hemodynamics in severe LV dysfunction; extends RCT comparisons of inotropes in cardiac surgery.
Does levosimendan better maintain postoperative cardiac function compared to milrinone in patients with severely compromised ventricular function undergoing elective cardiac surgery?
In cardiac surgery patients with severe left ventricular dysfunction, levosimendan combined with dobutamine better maintains postoperative stroke volume and reduces the need for additional inotropes compared to milrinone combined with dobutamine.
Hert et al. (2007) studied this question.
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