Why the study?
Does low-dose milrinone improve hemodynamics and reduce the need for vasoactive agents during weaning from cardiopulmonary bypass in patients with mitral stenosis and pulmonary hypertension?
Population
47 patients with rheumatic mitral stenosis and pulmonary hypertension undergoing mitral valve replacement.
Comparison
Milrinone. vs Control group (standard care).
Design
RCT, Randomized to the control and milrinone groups
Follow-up
7 days postoperatively
Authors
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Supports low-dose milrinone during CPB weaning in mitral stenosis with PH; extends RCT evidence for improved hemodynamics and reduced vasoactive needs.
Does low-dose milrinone improve hemodynamics and reduce the need for vasoactive agents during weaning from cardiopulmonary bypass in patients with mitral stenosis and pulmonary hypertension?
Low-dose milrinone administered during weaning from cardiopulmonary bypass safely improves pulmonary hemodynamics and reduces the need for additional vasoactive agents in patients with rheumatic mitral stenosis and pulmonary hypertension.
Öztekin et al. (2007) studied this question.
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