What question did this study set out to answer?

The study aims to investigate how phenol binds at two sites within the active site of carbonic anhydrase II and its structural implications for enzyme function.

April 1, 1994Journal of the American Chemical Society

Two-Site Binding of Phenol in the Active Site of Human Carbonic Anhydrase II: Structural Implications for Substrate Association

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Authors

SNSatish K. NairUniversity of Illinois Urbana-Champaign PLP. LudwigBASF (United States)DCDavid W. ChristiansonUniversity of Iowa Hospitals and Clinics

Discussion

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Implication

This research demonstrates the two-site binding of phenol in the active site of carbonic anhydrase II, highlighting structural implications for substrate association.

Key Points

The study aims to investigate how phenol binds at two sites within the active site of carbonic anhydrase II and its structural implications for enzyme function.
Structural analysis using X-ray crystallography to identify binding sites of phenol in carbonic anhydrase II.
Comparative studies with various substrates to assess binding affinities at the identified sites.
Phenol exhibits dual binding to the active site of carbonic anhydrase II, influencing substrate association.

Cite This Study

Nair et al. (1994) studied this question.

synapsesocial.com/papers/6a70945dac440176ef293ce6 https://doi.org/10.1021/ja00087a086

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Implication

This research demonstrates the two-site binding of phenol in the active site of carbonic anhydrase II, highlighting structural implications for substrate association.

Two-Site Binding of Phenol in the Active Site of Human Carbonic Anhydrase II: Structural Implications for Substrate Association

Discussion

Member takes

Implication

Key Points

Cite This Study

Two-Site Binding of Phenol in the Active Site of Human Carbonic Anhydrase II: Structural Implications for Substrate Association

Discussion

Member takes

Implication

Key Points

Cite This Study

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