Key result
High-dose garlic lowers sitting blood pressure by ~7/16 mm Hg in severe hypertension.
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A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, with a significant decrease in diastolic blood pressure (p < 0.05) from 5-14 hours after the dose. No significant side effects were reported. Our results indicate that this garlic preparation can reduce blood pressure. Further controlled studies are needed, particularly with more conventional doses (e.g., < or = 900 mg/day), in patients with mild to moderate hypertension and under placebo-controlled, double-blind conditions.
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McMahon et al. (1993) studied Severe hypertension (n=9). Garlic preparation (1.3% allicin) was evaluated on Change in sitting blood pressure (p=< 0.05). A dose of a garlic preparation decreased sitting blood pressure by 7/16 mm Hg at peak effect in patients with severe hypertension.
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