April 8, 2015International Journal of Stroke
A Pathological Perspective on the Natural History of Cerebral Atherosclerosis
Population
196 autopsy cases (cerebral large arteries)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Stenosis-based grading may underestimate intracranial atherosclerosis burden; leaves open the role of plaque imaging in noncardioembolic stroke.
Structured PICO
P
Population
196 autopsy cases (cerebral large arteries)
O
Outcome
Frequency of atherosclerotic lesions and degree of cross-sectional lumen stenosissurrogate
Advanced intracranial atherosclerosis frequently occurs without severe lumen stenosis, suggesting that relying solely on stenosis underestimates disease burden.
Cite This Study
Gutierrez et al. (2015) studied this question.