December 1, 1997American Journal of Kidney DiseasesOpen Access

Intradialytic hypotension: Is midodrine beneficial in symptomatic hemodialysis patients?

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Why the study?

Does midodrine improve blood pressure and symptoms in hemodialysis patients with persistent intradialytic hypotension?

Structured PICO

Does midodrine improve blood pressure and symptoms in hemodialysis patients with persistent intradialytic hypotension?

Population

10 hemodialysis patients with end-stage renal disease (ESRD) and persistent intradialytic hypotension

Intervention

Midodrine (mean dose 5.5 mg, range 5-10 mg) administered orally 30 minutes before each hemodialysis session for 10 consecutive sessions

Comparator

10 consecutive dialysis sessions off midodrine therapy (baseline/control period)

Outcome

Blood pressure (lowest intradialytic and posthemodialysis systolic, diastolic, and mean arterial pressure)surrogate

Administration of a single dose of midodrine before hemodialysis significantly improves intradialytic and posthemodialysis blood pressure and associated symptoms in patients with persistent intradialytic hypotension.

Limitations

Small sample size
Lack of long-term follow-up
Not a prospective trial

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for midodrine in persistent intradialytic hypotension; randomized trials needed before clinical adoption.

Cite This Study

Cruz et al. (1997) studied this question.

synapsesocial.com/papers/6a709571febe604dd7095a15 https://doi.org/10.1016/s0272-6386(97)90081-0

View Full Paper

Ask AI

Bookmark

Intradialytic hypotension: Is midodrine beneficial in symptomatic hemodialysis patients?

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Intradialytic hypotension: Is midodrine beneficial in symptomatic hemodialysis patients?

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider