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Unilateral explants of rat adrenal medullas grown in the anterior chamber of the eye contained very low phenylethanolamine-Nmethyl transferase (PNMT) activity. When animals were treated with dexamethasone for 7 days, PNMT activity rose more than 10-fold. These findings suggest that the increase in PNMT activity produced by glucocorticoids does not require an intact adrenal innervation. (Endocrinology 86: 1466, 1970)
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Pohorecky et al. (1970) studied this question.
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